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He also said that it is "a bad idea" to classify it as a drug. "I don't think it should be zoloft buy online called a drug and if does exist in the form it is today, should be made available to everyone," he said. "The idea behind the drug is not only that people will be obese, but that there will be fewer strokes and less cardiovascular disease."
But according to the American Heart Association, many of the studies cited by Fruchart to support the FDA's approval of Surolign are, in fact, "outdated" and "not reliable enough to justify the results."
That group points out many of the studies used to support Surolign label, like the one released last year by Stanford scientists, relied heavily on data from the original Phase II trial in which fewer than 25% of patients met their "metabolic criteria," which are lower than LDL cholesterol of 200mg per deciliter and a fasting blood sugar of over 130 mg/dl. Even with these criteria met, only 17% were prescribed Surolign, versus 58% who kept diet and exercise in place.
"Surolign works to lower LDL by about 30 to 40 points," Dr. Daniel Cohen, the medical director of Stanford Clinical Research Center, told HealthDay. "Those numbers may be small, but that's a huge difference compared to what doctors have been prescribing in the past."
As a result, Cohen said, his results suggest that patients who are on the Surolign regimen "may end up eating less and exercising more." he suggests that if patients are prescribed the drug and lose weight, it may result in less weight regain and improved lipids. But while Cohen's analysis is not definitive or the last word on this point, it doesn't offer support for the FDA's decision to approve Surolign on January 19.
According to the FDA, when compared patients taking another at-home cholesterol-lowering drug, rosuvastatin, when patients on zoloft cost usa the Surolign regimen lose more than 10 pounds, they have a 20% higher risk of having an event called a "metastomic ischemic coronary event." (Metastomas in the heart are rare, causing about 2,000 hospitalizations per year.) A metastomic ischemic event is an artery leak, rupture or death that results from an artery being leaky.
Yet, Dr. Daniel Carpenter, director of the Obesity and Diabetes Research Center at Harvard-affiliated Boston Children's Hospital, told HealthDay that his studies suggest Surolign may be more effective at lowering LDL "than what we did with rosuvastatin," which is what the FDA chose to approve on January 19. Carpenter said the effect of new drug can also be seen in patients taking statins, another class of drugs often used to reduce cholesterol.
"We're not against them, we're arguing them at all," Carpenter said. "It's just that the clinical trials were done 20 years ago."
Still, the problem with Surolign, says Mark Messier, of the American Council on Exercise, could be that most people, including those taking it to reduce their cholesterol, don't realize what it is.
"There is no label on the actual drug, only FDA-approved terms," he notes. "When people think of LDL as just fat and cholesterol, what you're really buying at a pharmacist counter is pharmaceutical term — a drug you're taking to do this thing in your body — and I don't believe there is any reason to think it's effective." After a long pause and moment of where to buy zoloft online silence during which many people in the audience stood and applauded, Hillary Rodham Clinton spoke.
"Thank you so much, very much. Thank you. So that's the end of this," she said to a roaring crowd, thanking the many thousands of supporters she will receive in the coming days to campaign.
It had been a day of high drama in the Democratic primary, with a resounding defeat for her rival, Barack Obama, in Maine leaving one of his most loyal bases still behind at his hotel there as he headed to the South on Thursday morning.
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